Create a personalised ads profile. Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. Marinol dronabinol is a synthetic form of tetrahydrocannabinol THC , the main psychoactive ingredient of marijuana cannabis. In addition to creating the "high" that many users seek, THC is known to reduce neuropathic pain, relieve nausea, and stimulate appetite.
While there remains no clear consensus as to which is "better" or "worse," there are pros and cons that may help direct your decision. Marinol was first approved by the U.
Food and Drug Administration FDA in to treat nausea and vomiting related to cancer chemotherapy. Its approval has since been extended to include the treatment of weight loss and anorexia in people with advanced HIV infection. As a result of its positive impact on people with HIV wasting , Marinol was rescheduled as a schedule III drug in meaning that it has an accepted medical use.
When used as prescribed, Marinol is considered safe and effective with a low risk of dependence. Off-label uses include the alleviation of fibromyalgia pain, glaucoma -related eye pressure, menstrual migraines, postoperative nausea and vomiting, obstructive sleep apnea, and muscle spasticity related to multiple sclerosis MS.
As a regulated pharmaceutical drug, Marinol and other THC derivatives have undergone extensive clinical research to support their use. While the pain-relieving effects of a mg dose of Marinol are comparable to a mg dose of codeine, higher doses are associated with a greater risk of side effects compared to codeine especially sedation. There are several benefits to Marinol, some of which stem from the fact that it is an FDA-approved drug.
They include:. Like any drug, Marinol also has cons to consider:. Marijuana is most commonly smoked but may also be added to food, ingested in tinctures and oils, or inhaled through vaporizers "vaping".
Medical marijuana was first legalized in California in at the height of the HIV crisis. Today, all but four U. With that being said, as a schedule I drug, marijuana has only been officially decriminalized in a handful of states.
Marinol is the brand name of a form of synthetic THC called dronabinol. While it shares the same chemical formula as the THC in marijuana, the elements are arranged differently within the molecule.
It consists of pure THC, which is dissolved in sesame oil and comes in pill form. There are also a host of potential adverse effects. Yechiel Gaoni and Raphael Mechoulam isolated deltatetrahydrocannabinol from the marijuana plant in In , the Controlled Substances Act classified the plant as a Schedule I drug with no recognized medical value and a high potential for abuse. The Act was a hammer blow to any hopes of researching marijuana and its cannabinoids in the United States.
While NCI studies found that some patients responded well to Marinol, six states conducted their own studies on marijuana. They discovered that patients found the THC in natural marijuana safer and more effective than the synthetic version.
Nonetheless, the government decided to proceed with Marinol. In , the United States Government sold the Marinol patent to Unimed, who applied to the FDA for permission to market the new drug as an anti-nausea treatment. The FDA initially denied the request in November because the clinical trial results were not promising. It was a significant move.
The reason for the boost is obvious. The scheduling of a drug impacts its level of market penetration. There is also the small matter of Schedule II prohibition of refills, quantity restrictions, and triplicate prescriptions. It is usually used as a last resort when other drugs have failed. Marinol is available in 2. The drug cost can vary significantly.
If patients use it without health insurance, a bottle with 60 x 2. However, there are plenty of ways to get a better price, including using a generic version. On drugs. In , the FDA approved Syndros, an oral solution form of dronabinol.
It is used to treat the same conditions as Marinol and was manufactured by the same company, Insys Therapeutics. It had hoped to breathe new life into its drug, but its market share has not grown to the level the firm had hoped. It is important to go to a doctor immediately if you faint, experience a rapid increase in heart rate, or a significant change in mental state after using Marinol. There is also a possibility that Marinol could lead to psychosis , particularly in those who have ever had depression or another mental illness.
It could increase or decrease blood pressure and is potentially habit-forming. Patients must never give Marinol to someone it is NOT prescribed for.
Also, it is extremely potent. Even 5mg is too much for some patients to deal with. This is because it could impair reaction or thinking times.
Individuals must wait until the effects wear off first. The body absorbs the dronabinol in Marinol similarly to the THC found in the marijuana plant. Marinol gets broken down and excreted in the urine for 48 hours to five weeks.
It is detectable in drug tests during this period. Please note that some of the dronabinol gets stored unchanged in fat cells. National Institute on Drug Abuse for Teens.
Origins: Ohio State University. National Institute on Drug Abuse. Deep Dive: Marijuana. National Conference of State Legislatures. But if you see something that doesn't look right, click here to contact us! Subscribe for fascinating stories connecting the past to the present.
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Early Opium Trade in the United As with most anti-drug initiatives, Just Say No—which became an American catch phrase in the s—evoked both support and criticism from the public.
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